rlightbox is a jQuery UI mediabox that can display many types of content such as images, YouTube and Vimeo videos. It has many unique features like Panorama and Live Re-size. Like other jQuery UI widgets, it is ThemeRoller ready.
prettyPhoto is a jQuery lightbox clone. Not only does it support images, it also support for videos, flash, YouTube, iframes and ajax. It’s a full blown media lightbox. It also comes with useful APIs so prettyPhoto can be launched from nearly anywhere.